"The conventional SARS-CoV-2 vaccine’s ability to provide immunological protection may be significantly impacted by over-vaccination. If this happens, either newly diagnosed COVID-19 cases or people who have already contracted the virus again may have a more severe case of the illness. This concept was proposed after seeing tolerance of both the humoral and cellular immune responses to prolonged booster immunization doses."
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However, a recent U.K. community-based population study found that those who have previously been infected with SARS-CoV-2, which causes COVID-19, demonstrate a lower rate of new Omicron BA.4/BA.5 infections compared to those who were vaccinated.