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The shipping crisis in California is now so bad that officials should consider declaring a state of emergency, the head of the California Trucking Association says

Officials in Southern California should consider declaring a state of emergency to help ease clogged ports in the area, a state trucking boss said.

In an interview with Fox News, Shawn Yadon, CEO of the California Trucking Association, said every stakeholder in the supply chain needed to act to fix the crisis – from shipping, trucking, and rail to warehousing. This echoed the sentiments of other experts

On Monday, the ports of Los Angeles and Long Beach hit a fresh record of 100 vessels floating off the coast waiting to dock and unload, according to data from the Marine Exchange.

Labor shortages along the supply chain, including trucking, had contributed to a “perfect storm” hitting ports, Yadon said, per Fox Business.

“I think we are in a situation in California where a state of emergency related to the ports is certainly something that should be considered,” he said.

Of the 100 ships waiting Monday, 97 were container ships, carrying cargo that could potentially miss the holiday shopping season.

Before the pandemic, the ports’ highest record had been 17 ships waiting to anchor, Kip Louttit, the head of the Marine Exchange told Insider this week.

Containers that have been stacked up on the docks for weeks are waiting to be unloaded, but a shortage of on-dock workers and truck drivers is leading to long delays in this process.

News of this record came days after the White House announced that the LA port would be following in the footsteps of its Long Beach neighbor and shifting to a 24-hours-a-day, seven-days-a-week schedule.

This week, the head of the American Trucking Associations told CNN that the country was currently lacking 80,000 truck drivers, a new record. 

The Three FDA Approved COVID Vaccine Big Pharma Companies All Employ Former FDA Commissioners

How can it be? The three FDA-authorized distributors of the highly controversial COVID vaccine all have under their employment former FDA Commissioners.

The Freedom First Network made the following observations about another revolving door, this time in the drug industry.

In today’s America, you can buy yourself a former FDA commissioner, and use the public-sector private-sector revolving door system of corruption to impose your will on the American public, and make a windfall for your executives and shareholders in the process.

That appears to be the exact strategy utilized by Johnson & Johnson, Pfizer, and the company that founded Moderna, which have rostered a series of former top ranking government officials into top positions in their respective organizations.

Former FDA Commissioner Scott Gottliebthe ultimate personification of the revolving door mechanism, sits on the board of Pfizer. The frequent Pfizer-sponsored CNBC guest also maintains several thousand shares of Pfizer stock, and he is compensated well into the six figures on an annual basis. Gottlieb earns millions from his continually increasing board appointments to a plethora of pharmaceutical and healthcare companies.

The pandemic profiteer also sits on the boards of Illumina and Tempus Labs, which sell FDA-authorized COVID-19 test kits. Additionally, he sits on the board of Aetion, which has partnered with the FDA on researching COVID-19 policy.

Stephen Hahn, who led the FDA when it authorized Moderna’s COVID shots, recently took an executive level post with Flagship Pioneering, the company that launched Moderna. Flagship holds 20 million shares of Moderna stock, which as of October 16, 2021, is valued at $6.5 Billion. They earned $1.4 billion through the sale of Moderna stock earlier this year…

…Mark McClellan was the FDA commissioner from 2002-2004 (and served in other high-ranking government posts). He has maintained a board of directors seat with pharma giant Johnson & Johnson since 2013. McClellan owns thousands of shares in the company and receives around $300,000 annually.

We see this now in multiple industries and government bodies.  Whether it be former Dominion employees working for the EAC, former Hedge fund managers working for the SEC, former generals working for the military complex, or former FDA Commissioners working for Big Pharma, the conflicts of interest are alarming.

This practice of movement between the government and big business is dangerous due to the conflicts of interest that arise and should be stopped.

NIH changes story, confirms it funded Wuhan experiment that made bat coronavirus more dangerous

Key scientist says admission shows that top administrators, including former NIH Director Francis Collins and NIAID Director Dr. Anthony Fauci, “lied to Congress, lied to the press, and lied to the public” in denying NIH funded gain-of-function research in Wuhan.

Two weeks after National Institutes of Health director Francis Collins announced his retirement, his agency has complicated congressional testimony by Collins and National Institute of Allergy and Infectious Diseases Director Anthony Fauci about alleged gain-of-function virus research sponsored by the U.S.

Both officials have denied approving grants for such research through the EcoHealth Alliance and Wuhan Institute of Virology, but a letter Wednesday from NIH Principal Deputy Director Lawrence Tabak to House Oversight Committee ranking Republican James Comer describes an unforeseen experimental result that calls the denials into question.

The letter shows that “NIH — and specifically, Collins, Fauci, and Tabak — lied to Congress, lied to the press, and lied to the public,” Richard Ebright, lab director at Rutgers University’s Waskman Institute of Microbiology, tweeted Wednesday night when sharing the letter. “Knowingly. Willfully. Brazenly.”

The final progress report submitted by EcoHealth in August described a “limited experiment” in which a modified bat coronavirus made mice “sicker” than the original virus, Tabak told Comer. “As sometimes occurs in science, this was an unexpected result of the research, as opposed to something that the researchers set out to do.”

NIH determined the proposed research didn’t meet the standard for “enhanced pathogens of pandemic potential” because it wasn’t shown these bat coronaviruses could infect humans. But “out of an abundance of caution” it required EcoHealth to “immediately” report “a one log increase in growth” if it happened, which would trigger a secondary review of the research by NIH.

EcoHealth didn’t do that, Tabak wrote, and it now has five days to turn over “any and all unpublished data” from the research to NIH.

The letter repeatedly emphasizes the viruses studied under the EcoHealth grant and “subaward” to the Wuhan lab “could not have become SARS-CoV-2” because the “sequences of the viruses are genetically very distinct.”

Reporting last month by The Intercept confirms that EcoHealth violated the NIH grant terms “at least four” times, Ebright tweeted earlier this month.

NIH put out a statement Wednesday on “misinformation” about COVID-19 origins that emphasizes “the virus is likely the result of viral evolution in nature” and not developed as a “biological weapon.” It does not mention EcoHealth’s violation of grant terms or the creation of a virus that made mice sicker.

Condoleezza Rice Blasts Critical Race Theory: “I Don’t Have To Make White Kids Feel Bad For Being White”

“This is a conversation that has gone in the wrong direction.”

Former Secretary of State Condoleezza Rice criticised proponents of Critical Race Theory Wednesday, declaring that “this is a conversation that has gone in the wrong direction.”

Appearing on The View, Rice, now the Director of the Hoover Institution, addressed CRT following the Biden administration’s apparent desire to punish parents who stand up against it being taught to their children in schools.

“If I could take a moment to talk about the whole issue of Critical Race Theory and what is, and is not being taught, I come out of an academic institution, and this is something that academics debate. What is the role of race and so forth?” Rice said. 

She continued, “let me be very clear; I grew up in segregated, Birmingham, Alabama. I couldn’t go to a movie theater, or to a restaurant with my parents. I went to segregated schools till we moved to Denver. My parents never thought I was going to grow up in a world without prejudice, but they also told me, ‘That’s somebody else’s problem, not yours. You’re going to overcome it, and you are going to be anything you want to be.’ And that’s the message that I think we ought to be sending to kids.”

“One of the worries that I have about the way that we’re talking about race is that it either seems so big that somehow white people now have to feel guilty for everything that happened in the past,” Rice further emphasised.

“I don’t think that’s very productive,” she then declared, adding “Or black people have to feel disempowered by race. I would like black kids to be completely empowered, to know that they are beautiful in their blackness, but in order to do that, I don’t have to make white kids feel bad for being white. So somehow, this is a conversation that has gone in the wrong direction.”

Watch:

It seems Rice is now pro-slavery… and racist… and not a real person of colour… or something:

Rice’s comments come in the wake of video emerging of a teacher at a high school in Ohio talking about books and themes closely associated with CRT, despite previous promises to parents from officials that it wasn’t happening in the district’s schools.

Fans Heap Praise on In-N-Out For Bold Stance Against Vax Mandate

The fast-food chain In-N-Out Burger made headlines this week when it announced it would not enforce a COVID-19 vaccination mandate for patrons in San Francisco, stating its role is not “to become the vaccination police for any government.”

Immediately, the California-based restaurant was met with praise.

“Who said corporations can’t act heroically?” wrote Sen. Rand Paul (R-Ky.).

The deluge of praise for In-N-Out Burger — owned by devout Christian Lynsi Snyder — came after the San Francisco Department of Public Health shuttered the location on Fisherman’s Wharf on Oct. 14, citing the restaurant’s failure to check patrons’ vaccination status, a violation of a city edict put in place in August.

In response, Arnie Wensinger, chief legal and business officer for In-N-Out Burger, told Fox News the restaurant locations contain “clearly posted signage to communicate local vaccination requirements.”

“After closing our restaurant, local regulators informed us that our restaurant associates must actively intervene by demanding proof of vaccination and photo identification from every customer, then act as enforcement personnel by barring entry for any customers without the proper documentation,” Wensinger said. “We refuse to become the vaccination police for any government.”

He went on to condemn the city health department for its “unreasonable, invasive, and unsafe” requirements, accusing the city of asking business owners to “segregate” their customers.

“We fiercely disagree with any government dictate that forces a private company to discriminate against customers who choose to patronize their business,” his statement continued. “This is clear governmental overreach and is intrusive, improper, and offensive.”

The pushback from In-N-Out Burger comes weeks after President Joe Biden mandated all private-sector companies with 100 or more employees require their staffers to show proof of vaccination against COVID-19.

It’s worth noting language to back up Biden’s edict has not yet been finalized. Last week, the president said his mandate will take effect “soon” because there are an “unacceptably high number” of people who have refused — for various reasons — to take the shots.

Without taking any questions from reporters, Biden said the government has “to do more to vaccinate 66 million unvaccinated people in America.”

President Trump Launches Media Platform ‘Truth Social’

Trump’s new social media platform will feature a subscription video service and will “stand up to the tyranny of big tech.”

QUICK FACTS:
  • President Donald Trump has announced plans to launch his own social media network, TRUTH Social, which will compete with Silicon Valley, according to The Daily Mail.
  • The network launches in early 2022 under a merger between Trump Media & Tech Group (TMTG) and Digital World Acquisitions Corp.
  • The TRUTH Social app is currently available for pre-order on the Apple App store, the beta version to launch in November.
  • Users can subscribe to the waiting at TruthSocial.com.
  • “I created TRUTH Social and TMTG to stand up to the tyranny of Big Tech,” Trump said in a press release.
  • CNBC noted the stock price of Digital World Acquisition Corp. (DWAC) “rocketed up more than 90% in trading after news of a merger.”
Screenshot taken from TruthSocial.com on October 21, 2021.
WHAT TRUMP SAID:
  • “We live in a world where the Taliban has a huge presence on Twitter, yet your favorite American President has been silenced. This is unacceptable. I am excited to send out my first TRUTH on TRUTH Social very soon,” Trump went on to say.
  • “TMTG was founded with a mission to give a voice to all. I’m excited to soon begin sharing my thoughts on TRUTH Social and to fight back against Big Tech,” he continued. “Everyone asks me why doesn’t someone stand up to Big Tech? Well, we will be soon!”
WHAT ELSE?
  • Daily Mail reports that along with social media service, TMTG also plans to launch a subscription video on-demand service called “TMTG+,” which it says will feature “non-woke” entertainment programming, news, podcasts, and more.
  • TMTG is expected to have an initial value of $875 million, with a potential additional earnout of $825 million, combined to a total $1.7 billion, notes Daily Mail.
MORE FROM THE PRESS RELEASE:

Trump Media & Technology Group and Digital World Acquisition Corp. (NASDAQ: DWAC) have entered into a definitive merger agreement, providing for a business combination that will result in Trump Media & Technology Group becoming a publicly listed company, subject to regulatory and stockholder approval. The transaction values Trump Media & Technology Group at an initial enterprise value of $875 Million, with a potential additional earnout of $825 Million in additional shares (at the valuation they are granted) for a cumulative valuation of up to $1.7 Billion depending on the performance of the stock price post-business combination. Trump Media & Technology Group’s growth plans initially will be funded by DWAC’s cash in trust of $293 Million (assuming no redemptions).

Trump Media & Technology Group’s mission is to create a rival to the liberal media consortium and fight back against the “Big Tech” companies of Silicon Valley, which have used their unilateral power to silence opposing voices in America.

Jon Fleetwood is Managing Editor for American Faith and author of “An American Revival: Why American Christianity Is Failing & How to Fix It.”

Jordan Peterson’s Daughter Mikhaila Confesses She ‘Found God’ (Video)

“I found God.”

QUICK FACTS:
  • Mikhaila Peterson revealed during a podcast that she’s been “reading the Bible and praying” and as a result has felt a peace “that I haven’t had before.”
  • Her spiritual change was due to recent “rough experiences,” according to Mikhaila.
  • After asking God to reveal himself to her the night before, Mikhaila explained the following morning she “woke up with this sense of calm I hadn’t felt—this sense of calm right here,” she said while pointing to her heart.
  • Mikhaila went on to describe a dream she had in which a “loud, thundering voice” told her to “Do it!” which she interprets as God challenging her to “go all-in” with her faith.
WATCH MIKHAILA EXPLAIN HER EXPERIENCE:
BACKGROUND:
  • American Faith reported in March how Jordan Peterson—author of 12 Rules for Life and Beyond Order—had also revealed that he believes in Jesus Christ as a real, historical figure.
  • “[S]o what you have in the figure of Christ is an actual person who actually lived plus a myth, and, in some sense, Christ is the union of those two things,” Peterson explained, adding, while holding back tears, “I probably believe that but I’m amazed at my own belief, and I don’t understand it.”

Jon Fleetwood is Managing Editor for American Faith and author of “An American Revival: Why American Christianity Is Failing & How to Fix It.”


81 Research Studies Confirm Natural Immunity to COVID ‘Equal’ or ‘Superior’ to Vaccine Immunity

The Brownstone Institute lists 81 of the highest-quality, complete, most robust scientific studies and evidence reports/position statements on natural immunity as compared to the COVID-19 vaccine-induced immunity.

We should not force COVID vaccines on anyone when the evidence shows that naturally acquired immunity is equal to or more robust and superior to existing vaccines. Instead, we should respect the right of the bodily integrity of individuals to decide for themselves.

Public health officials and the medical establishment with the help of the politicized media are misleading the public with assertions that the COVID-19 shots provide greater protection than natural immunity.

Centers for Disease Control and Prevention (CDC) Director Rochelle Walensky, for example, was deceptive in her October 2020 published LANCET statement that “there is no evidence for lasting protective immunity to SARS-CoV-2 following natural infection” and that “the consequence of waning immunity would present a risk to vulnerable populations for the indefinite future.”

Immunology and virology 101 have taught us over a century that natural immunity confers protection against a respiratory virus’s outer coat proteins, and not just one, e.g., the SARS-CoV-2 spike glycoprotein.

There is even strong evidence for the persistence of antibodies. Even the CDC recognizes natural immunity for chicken-pox and measles, mumps and rubella, but not for COVID-19.

The vaccinated are showing viral loads (very high) similar to the unvaccinated, and the vaccinated are as infectious. Riemersma et al. also report Wisconsin data that corroborate how the vaccinated individuals who get infected with the Delta variant can potentially (and are) transmit(ting) SARS-CoV-2 to others (potentially to the vaccinated and unvaccinated).

This troubling situation of the vaccinated being infectious and transmitting the virus emerged in seminal nosocomial outbreak papers by Chau et al. (HCWs in Vietnam), the Finland hospital outbreak (spread among HCWs and patients), and the Israel hospital outbreak (spread among HCWs and patients).

These studies also revealed that the personal protective equipment (PPE) and masks were essentially ineffective in the healthcare setting. Again, the Marek’s disease in chickens and the vaccination situation explains what we are potentially facing with these leaky vaccines (increased transmission, faster transmission, and more ‘hotter’ variants).

Moreover, existing immunity should be assessed before any vaccination, via an accurate, dependable and reliable antibody test (or T cell immunity test) or be based on documentation of prior infection (a previous positive PCR or antigen test). Such would be evidence of immunity that is equal to that of vaccination and the immunity should be provided the same societal status as any vaccine-induced immunity.

This will function to mitigate the societal anxiety with these forced vaccine mandates and societal upheaval due to job loss, denial of societal privileges etc. Tearing apart the vaccinated and the unvaccinated in a society — separating them — is not medically or scientifically supportable.

The Brownstone Institute previously documented 30 studies on natural immunity as it relates to COVID-19.

This follow-up chart is the most updated and comprehensive library list of 81 of the highest-quality, complete, most robust scientific studies and evidence reports/position statements on natural immunity as compared to the COVID-19 vaccine-induced immunity and allows you to draw your own conclusion.

I’ve benefited from the input of many to put this together, especially my co-authors:

  • Dr. Harvey Risch, M.D., Ph.D. (Yale School of Public Health)
  • Dr. Howard Tenenbaum, Ph.D. ( Faculty of Medicine, University of Toronto)
  • Dr. Ramin Oskoui, M.D. (Foxhall Cardiology, Washington)
  • Dr. Peter McCullough, M.D. (Truth for Health Foundation, Texas)
  • Dr. Parvez Dara, M.D. (consultant, Medical Hematologist and Oncologist)

Evidence on natural immunity versus COVID-19 vaccine induced immunity as of Oct. 15:

Study / report title, author, and year publishedPredominant finding on natural immunity
1) Necessity of COVID-19 vaccination in previously infected individuals, Shrestha, 2021“Cumulative incidence of COVID-19 was examined among 52,238 employees in an American healthcare system.
“The cumulative incidence of SARS-CoV-2 infection remained almost zero among previously infected unvaccinated subjects, previously infected subjects who were vaccinated, and previously uninfected subjects who were vaccinated, compared with a steady increase in cumulative incidence among previously uninfected subjects who remained unvaccinated.
“Not one of the 1359 previously infected subjects who remained unvaccinated had a SARS-CoV-2 infection over the duration of the study. Individuals who have had SARS-CoV-2 infection are unlikely to benefit from COVID-19 vaccination…”
2) SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls, Le Bert, 2020“Studied T cell responses against the structural (nucleocapsid (N) protein) and non-structural (NSP7 and NSP13 of ORF1) regions of SARS-CoV-2 in individuals convalescing from coronavirus disease 2019 (COVID-19) (n = 36).
“In all of these individuals, we found CD4 and CD8 T cells that recognized multiple regions of the N protein … showed that patients (n = 23) who recovered from SARS possess long-lasting memory T cells that are reactive to the N protein of SARS-CoV 17 years after the outbreak of SARS in 2003; these T cells displayed robust cross-reactivity to the N protein of SARS-CoV-2.”
3) Comparing SARS-CoV-2 natural immunity to vaccine-induced immunity: reinfections versus breakthrough infections, Gazit, 2021“A retrospective observational study comparing three groups:
“(1) SARS-CoV-2-naïve individuals who received a two-dose regimen of the BioNTech/Pfizer mRNA BNT162b2 vaccine, (2) previously infected individuals who have not been vaccinated and (3) previously infected and single dose vaccinated individuals, found para a 13 fold increased risk of breakthrough Delta infections in double vaccinated persons, and a 27 fold increased risk for symptomatic breakthrough infection in the double vaccinated relative to the natural immunity recovered persons …
“ … the risk of hospitalization was 8 times higher in the double vaccinated (para) … this analysis demonstrated that natural immunity affords longer lasting and stronger protection against infection, symptomatic disease and hospitalization due to the Delta variant of SARS-CoV-2, compared to the BNT162b2 two-dose vaccine-induced immunity.”
4) Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection, Le Bert, 2021“Studied SARS-CoV-2–specific T cells in a cohort of asymptomatic (n = 85) and symptomatic (n = 75) COVID-19 patients after seroconversion …“thus, asymptomatic SARS-CoV-2–infected individuals are not characterized by weak antiviral immunity; on the contrary, they mount a highly functional virus-specific cellular immune response.”
5) Large-scale study of antibody titer decay following BNT162b2 mRNA vaccine or SARS-CoV-2 infection, Israel, 2021“A total of 2,653 individuals fully vaccinated by two doses of vaccine during the study period and 4,361 convalescent patients were included.
“Higher SARS-CoV-2 IgG antibody titers were observed in vaccinated individuals (median 1581 AU/mL IQR [533.8-5644.6]) after the second vaccination, than in convalescent individuals (median 355.3 AU/mL IQR [141.2-998.7]; p<0.001).
“In vaccinated subjects, antibody titers decreased by up to 40% each subsequent month while in convalescents they decreased by less than 5% per month …
“this study demonstrates individuals who received the Pfizer-BioNTech mRNA vaccine have different kinetics of antibody levels compared to patients who had been infected with the SARS-CoV-2 virus, with higher initial levels but a much faster exponential decrease in the first group.”
6) SARS-CoV-2 re-infection risk in Austria, Pilz, 2021Researchers recorded:
“40 tentative re-infections in 14, 840 COVID-19 survivors of the first wave (0.27%) and 253 581 infections in 8, 885, 640 individuals of the remaining general population (2.85%) translating into an odds ratio (95% confidence interval) of 0.09 (0.07 to 0.13)…relatively low re-infection rate of SARS-CoV-2 in Austria.
“Protection against SARS-CoV-2 after natural infection is comparable with the highest available estimates on vaccine efficacies.”
Additionally, hospitalization in only five out of 14,840 (0.03%) people and death in one out of 14,840 (0.01%) (tentative re-infection).
7) mRNA vaccine-induced SARS-CoV-2-specific T cells recognize B.1.1.7 and B.1.351 variants but differ in longevity and homing properties depending on prior infection status, Neidleman, 2021“Spike-specific T cells from convalescent vaccinees differed strikingly from those of infection-naïve vaccinees, with phenotypic features suggesting superior long-term persistence and ability to home to the respiratory tract including the nasopharynx.
“These results provide reassurance that vaccine-elicited T cells respond robustly to the B.1.1.7 and B.1.351 variants, confirm that convalescents may not need a second vaccine dose.”
8) Good news: Mild COVID-19 induces lasting antibody protection, Bhandari, 2021“Months after recovering from mild cases of COVID-19, people still have immune cells in their body pumping out antibodies against the virus that causes COVID-19, according to a study from researchers at Washington University School of Medicine in St. Louis.
“Such cells could persist for a lifetime, churning out antibodies all the while.
“The findings, published May 24 in the journal Nature, suggest that mild cases of COVID-19 leave those infected with lasting antibody protection and that repeated bouts of illness are likely to be uncommon.”
9) Robust neutralizing antibodies to SARS-CoV-2 infection persist for months, Wajnberg, 2021“Neutralizing antibody titers against the SARS-CoV-2 spike protein persisted for at least 5 months after infection.
“Although continued monitoring of this cohort will be needed to confirm the longevity and potency of this response, these preliminary results suggest that the chance of reinfection may be lower than is currently feared.”
10) Evolution of antibody immunity to SARS-CoV-2, Gaebler, 2020“Concurrently, neutralizing activity in plasma decreases by five-fold in pseudo-type virus assays. In contrast, the number of RBD-specific memory B cells is unchanged.
“Memory B cells display clonal turnover after 6.2 months, and the antibodies they express have greater somatic hypermutation, increased potency and resistance to RBD mutations, indicative of continued evolution of the humoral response …
“we conclude that the memory B cell response to SARS-CoV-2 evolves between 1.3 and 6.2 months after infection in a manner that is consistent with antigen persistence.”
11) Persistence of neutralizing antibodies a year after SARS-CoV-2 infection in humans, Haveri, 2021“Assessed the persistence of serum antibodies following WT SARS-CoV-2 infection at 8 and 13 months after diagnosis in 367 individuals …
“found that NAb against the WT virus persisted in 89% and S-IgG in 97% of subjects for at least 13 months after infection.”
12) Quantifying the risk of SARS‐CoV‐2 reinfection over time, Murchu, 2021“Eleven large cohort studies were identified that estimated the risk of SARS‐CoV‐2 reinfection over time, including three that enrolled healthcare workers and two that enrolled residents and staff of elderly care homes.
“Across studies, the total number of PCR‐positive or antibody‐positive participants at baseline was 615,777, and the maximum duration of follow‐up was more than 10 months in three studies.
“Reinfection was an uncommon event (absolute rate 0%–1.1%), with no study reporting an increase in the risk of reinfection over time.”
13) Natural immunity to COVID is powerful. Policymakers seem afraid to say so, Makary, 2021Makary writes “it’s okay to have an incorrect scientific hypothesis. But when new data proves it wrong, you have to adapt.
“Unfortunately, many elected leaders and public health officials have held on far too long to the hypothesis that natural immunity offers unreliable protection against covid-19 — a contention that is being rapidly debunked by science.
“More than 15 studies have demonstrated the power of immunity acquired by previously having the virus.
“A 700,000-person study from Israel two weeks ago found that those who had experienced prior infections were 27 times less likely to get a second symptomatic covid infection than those who were vaccinated.
“This affirmed a June Cleveland Clinic study of health-care workers (who are often exposed to the virus), in which none who had previously tested positive for the coronavirus got reinfected.
“The study authors concluded that ‘individuals who have had SARS-CoV-2 infection are unlikely to benefit from covid-19 vaccination.’
“And in May, a Washington University study found that even a mild covid infection resulted in long-lasting immunity.”
14) SARS-CoV-2 elicits robust adaptive immune responses regardless of disease severity, Nielsen, 2021“203 recovered SARS-CoV-2 infected patients in Denmark between April 3rd and July 9th 2020, at least 14 days after COVID-19 symptom recovery …
“report broad serological profiles within the cohort, detecting antibody binding to other human coronaviruses … the viral surface spike protein was identified as the dominant target for both neutralizing antibodies and CD8+ T-cell responses.
“Overall, the majority of patients had robust adaptive immune responses, regardless of their disease severity.”
15) Protection of previous SARS-CoV-2 infection is similar to that of BNT162b2 vaccine protection: A three-month nationwide experience from Israel, Goldberg, 2021“Analyze an updated individual-level database of the entire population of Israel to assess the protection efficacy of both prior infection and vaccination in preventing subsequent SARS-CoV-2 infection, hospitalization with COVID-19, severe disease, and death due to COVID-19 …
“vaccination was highly effective with overall estimated efficacy for documented infection of 92·8% (CI:[92·6, 93·0]); hospitalization 94·2% (CI:[93·6, 94·7]); severe illness 94·4% (CI:[93·6, 95·0]); and death 93·7% (CI:[92·5, 94·7]).
“Similarly, the overall estimated level of protection from prior SARS-CoV-2 infection for documented infection is 94·8% (CI: [94·4, 95·1]); hospitalization 94·1% (CI: [91·9, 95·7]); and severe illness 96·4% (CI: [92·5, 98·3])…results question the need to vaccinate previously-infected individuals.”
16) Incidence of Severe Acute Respiratory Syndrome Coronavirus-2 infection among previously infected or vaccinated employees, Kojima, 2021“Employees were divided into three groups: (1) SARS-CoV-2 naïve and unvaccinated, (2) previous SARS-CoV-2 infection, and (3) vaccinated.
“Person-days were measured from the date of the employee first test and truncated at the end of the observation period. SARS-CoV-2 infection was defined as two positive SARS-CoV-2 PCR tests in a 30-day period …
“4313, 254 and 739 employee records for groups 1, 2, and 3 … previous SARS-CoV-2 infection and vaccination for SARS-CoV-2 were associated with decreased risk for infection or re-infection with SARS-CoV-2 in a routinely screened workforce.
“There was no difference in the infection incidence between vaccinated individuals and individuals with previous infection.”
17) Having SARS-CoV-2 once confers much greater immunity than a vaccine — but vaccination remains vital, Wadman, 2021“Israelis who had an infection were more protected against the Delta coronavirus variant than those who had an already highly effective COVID-19 vaccine …
“the newly released data show people who once had a SARS-CoV-2 infection were much less likely than never-infected, vaccinated people to get Delta, develop symptoms from it, or become hospitalized with serious COVID-19.”
18) One-year sustained cellular and humoral immunities of COVID-19 convalescents, Zhang, 2021“A systematic antigen-specific immune evaluation in 101 COVID-19 convalescents; SARS-CoV-2-specific IgG antibodies, and also NAb can persist among over 95% COVID-19 convalescents from 6 months to 12 months after disease onset.
“At least 19/71 (26%) of COVID-19 convalescents (double positive in ELISA and MCLIA) had detectable circulating IgM antibody against SARS-CoV-2 at 12m post-disease onset.
“Notably, the percentages of convalescents with positive SARS-CoV-2-specific T-cell responses (at least one of the SARS-CoV-2 antigen S1, S2, M and N protein) were 71/76 (93%) and 67/73 (92%) at 6m and 12m, respectively.”
19) Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19, Rodda, 2021“Recovered individuals developed SARS-CoV-2-specific immunoglobulin (IgG) antibodies, neutralizing plasma, and memory B and memory T cells that persisted for at least 3 months.
“Our data further reveal that SARS-CoV-2-specific IgG memory B cells increased over time.
“Additionally, SARS-CoV-2-specific memory lymphocytes exhibited characteristics associated with potent antiviral function: memory T cells secreted cytokines and expanded upon antigen re-encounter, whereas memory B cells expressed receptors capable of neutralizing virus when expressed as monoclonal antibodies.
“Therefore, mild COVID-19 elicits memory lymphocytes that persist and display functional hallmarks of antiviral immunity.”
20) Discrete Immune Response Signature to SARS-CoV-2 mRNA Vaccination Versus Infection, Ivanova, 2021“Performed multimodal single-cell sequencing on peripheral blood of patients with acute COVID-19 and healthy volunteers before and after receiving the SARS-CoV-2 BNT162b2 mRNA vaccine to compare the immune responses elicited by the virus and by this vaccine …
“both infection and vaccination induced robust innate and adaptive immune responses, our analysis revealed significant qualitative differences between the two types of immune challenges.
“In COVID-19 patients, immune responses were characterized by a highly augmented interferon response which was largely absent in vaccine recipients.
“Increased interferon signaling likely contributed to the observed dramatic upregulation of cytotoxic genes in the peripheral T cells and innate-like lymphocytes in patients but not in immunized subjects.
“Analysis of B and T cell receptor repertoires revealed that while the majority of clonal B and T cells in COVID-19 patients were effector cells, in vaccine recipients clonally expanded cells were primarily circulating memory cells …
“we observed the presence of cytotoxic CD4 T cells in COVID-19 patients that were largely absent in healthy volunteers following immunization.
“While hyper-activation of inflammatory responses and cytotoxic cells may contribute to immunopathology in severe illness, in mild and moderate disease, these features are indicative of protective immune responses and resolution of infection.”
21) SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans, Turner, 2021“Bone marrow plasma cells (BMPCs) are a persistent and essential source of protective antibodies …
“durable serum antibody titres are maintained by long-lived plasma cells — non-replicating, antigen-specific plasma cells that are detected in the bone marrow long after the clearance of the antigen …
“S-binding BMPCs are quiescent, which suggests that they are part of a stable compartment.
“Consistently, circulating resting memory B cells directed against SARS-CoV-2 S were detected in the convalescent individuals.
“Overall, our results indicate that mild infection with SARS-CoV-2 induces robust antigen-specific, long-lived humoral immune memory in humans …
“overall, our data provide strong evidence that SARS-CoV-2 infection in humans robustly establishes the two arms of humoral immune memory: long-lived bone marrow plasma cells (BMPCs) and memory B-cells.”
22) SARS-CoV-2 infection rates of antibody-positive compared with antibody-negative health-care workers in England: a large, multicentre, prospective cohort study (SIREN), Jane Hall, 2021“The SARS-CoV-2 Immunity and Reinfection Evaluation study… 30 625 participants were enrolled into the study …
“a previous history of SARS-CoV-2 infection was associated with an 84% lower risk of infection, with median protective effect observed 7 months following primary infection.
“This time period is the minimum probable effect because seroconversions were not included. This study shows that previous infection with SARS-CoV-2 induces effective immunity to future infections in most individuals.”
23) Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers, Houlihan, 2020“Enrolled 200 patient-facing HCWs between March 26 and April 8, 2020 … represents a 13% infection rate (i.e. 14 of 112 HCWs) within the 1 month of follow-up in those with no evidence of antibodies or viral shedding at enrolment.
“By contrast, of 33 HCWs who tested positive by serology but tested negative by RT-PCR at enrolment, 32 remained negative by RT-PCR through follow-up, and one tested positive by RT-PCR on days 8 and 13 after enrolment.”
24) Antibodies to SARS-CoV-2 are associated with protection against reinfection, Lumley, 2021“Critical to understand whether infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) protects from subsequent reinfection …
“12219 HCWs participated…prior SARS-CoV-2 infection that generated antibody responses offered protection from reinfection for most people in the six months following infection.”
25) Longitudinal analysis shows durable and broad immune memory after SARS-CoV-2 infection with persisting antibody responses and memory B and T cells, Cohen, 2021“Evaluate 254 COVID-19 patients longitudinally up to 8 months and find durable broad-based immune responses.
“SARS-CoV-2 spike binding and neutralizing antibodies exhibit a bi-phasic decay with an extended half-life of >200 days suggesting the generation of longer-lived plasma cells …
“most recovered COVID-19 patients mount broad, durable immunity after infection, spike IgG+ memory B cells increase and persist post-infection, durable polyfunctional CD4 and CD8 T cells recognize distinct viral epitope regions.”
26) Single cell profiling of T and B cell repertoires following SARS-CoV-2 mRNA vaccine, Sureshchandra, 2021“Used single-cell RNA sequencing and functional assays to compare humoral and cellular responses to two doses of mRNA vaccine with responses observed in convalescent individuals with asymptomatic disease …
“natural infection induced expansion of larger CD8 T cell clones occupied distinct clusters, likely due to the recognition of a broader set of viral epitopes presented by the virus not seen in the mRNA vaccine.”
27) SARS-CoV-2 antibody-positivity protects against reinfection for at least seven months with 95% efficacy, Abu-Raddad, 2021“SARS-CoV-2 antibody-positive persons from April 16 to December 31, 2020 with a PCR-positive swab ≥14 days after the first-positive antibody test were investigated for evidence of reinfection, 43,044 antibody-positive persons who were followed for a median of 16.3 weeks … reinfection is rare in the young and international population of Qatar.
“Natural infection appears to elicit strong protection against reinfection with an efficacy ~95% for at least seven months.”
28) Orthogonal SARS-CoV-2 Serological Assays Enable Surveillance of Low-Prevalence Communities and Reveal Durable Humoral Immunity, Ripperger, 2020“Conducted a serological study to define correlates of immunity against SARS-CoV-2.
“Compared to those with mild coronavirus disease 2019 (COVID-19) cases, individuals with severe disease exhibited elevated virus-neutralizing titers and antibodies against the nucleocapsid (N) and the receptor binding domain (RBD) of the spike protein…neutralizing and spike-specific antibody production persists for at least 5–7 months …
“nucleocapsid antibodies frequently become undetectable by 5–7 months.”
29) Anti-spike antibody response to natural SARS-CoV-2 infection in the general population, Wei, 2021“In the general population using representative data from 7,256 United Kingdom COVID-19 infection survey participants who had positive swab SARS-CoV-2 PCR tests from 26-April-2020 to 14-June-2021 …
“we estimated antibody levels associated with protection against reinfection likely last 1.5-2 years on average, with levels associated with protection from severe infection present for several years.
“These estimates could inform planning for vaccination booster strategies.”
30) Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Workers, Lumley, 2021“12,541 health care workers participated and had anti-spike IgG measured; 11,364 were followed up after negative antibody results and 1265 after positive results, including 88 in whom seroconversion occurred during follow-up …
“a total of 223 anti-spike–seronegative health care workers had a positive PCR test (1.09 per 10,000 days at risk), 100 during screening while they were asymptomatic and 123 while symptomatic, whereas 2 anti-spike–seropositive health care workers had a positive PCR test …
“the presence of anti-spike or anti-nucleocapsid IgG antibodies was associated with a substantially reduced risk of SARS-CoV-2 reinfection in the ensuing 6 months.”
31) Researchers find long-lived immunity to 1918 pandemic virus, CIDRAP, 2008and the actual 2008 NATURE journal publication by Yu“A study of the blood of older people who survived the 1918 influenza pandemic reveals that antibodies to the strain have lasted a lifetime and can perhaps be engineered to protect future generations against similar strains …
“the group collected blood samples from 32 pandemic survivors aged 91 to 101 … the people recruited for the study were 2 to 12 years old in 1918 and many recalled sick family members in their households, which suggests they were directly exposed to the virus, the authors report.
“The group found that 100% of the subjects had serum-neutralizing activity against the 1918 virus and 94% showed serologic reactivity to the 1918 hemagglutinin. The investigators generated B lymphoblastic cell lines from the peripheral blood mononuclear cells of eight subjects.
“Transformed cells from the blood of 7 of the 8 donors yielded secreting antibodies that bound the 1918 hemagglutinin.”
“Yu: ‘here we show that of the 32 individuals tested that were born in or before 1915, each showed sero-reactivity with the 1918 virus, nearly 90 years after the pandemic. Seven of the eight donor samples tested had circulating B cells that secreted antibodies that bound the 1918 HA.
“We isolated B cells from subjects and generated five monoclonal antibodies that showed potent neutralizing activity against 1918 virus from three separate donors. These antibodies also cross-reacted with the genetically similar HA of a 1930 swine H1N1 influenza strain.’”
32) Live virus neutralisation testing in convalescent patients and subjects vaccinated against 19A, 20B, 20I/501Y.V1 and 20H/501Y.V2 isolates of SARS-CoV-2, Gonzalez, 2021“No significant difference was observed between the 20B and 19A isolates for HCWs with mild COVID-19 and critical patients. However, a significant decrease in neutralisation ability was found for 20I/501Y.V1 in comparison with 19A isolate for critical patients and HCWs 6-months post infection.
“Concerning 20H/501Y.V2, all populations had a significant reduction in neutralising antibody titres in comparison with the 19A isolate.
“Interestingly, a significant difference in neutralisation capacity was observed for vaccinated HCWs between the two variants whereas it was not significant for the convalescent groups …
“the reduced neutralising response observed towards the 20H/501Y.V2 in comparison with the 19A and 20I/501Y.V1 isolates in fully immunized subjects with the BNT162b2 vaccine is a striking finding of the study.”
33) Differential effects of the second SARS-CoV-2 mRNA vaccine dose on T cell immunity in naïve and COVID-19 recovered individuals, Camara, 2021“Characterized SARS-CoV-2 spike-specific humoral and cellular immunity in naïve and previously infected individuals during full BNT162b2 vaccination …results demonstrate that the second dose increases both the humoral and cellular immunity in naïve individuals.
“On the contrary, the second BNT162b2 vaccine dose results in a reduction of cellular immunity in COVID-19 recovered individuals.”
34) Op-Ed: Quit Ignoring Natural COVID Immunity, Klausner, 2021“Epidemiologists estimate over 160 million people worldwide have recovered from COVID-19. Those who have recovered have an astonishingly low frequency of repeat infection, disease, or death.”
35) Association of SARS-CoV-2 Seropositive Antibody Test With Risk of Future Infection, Harvey, 2021“To evaluate evidence of SARS-CoV-2 infection based on diagnostic nucleic acid amplification test (NAAT) among patients with positive vs negative test results for antibodies in an observational descriptive cohort study of clinical laboratory and linked claims data …
“the cohort included 3 257 478 unique patients with an index antibody test … patients with positive antibody test results were initially more likely to have positive NAAT results, consistent with prolonged RNA shedding, but became markedly less likely to have positive NAAT results over time, suggesting that seropositivity is associated with protection from infection.”
36) SARS-CoV-2 seropositivity and subsequent infection risk in healthy young adults: a prospective cohort study, Letizia, 2021“Investigated the risk of subsequent SARS-CoV-2 infection among young adults (CHARM marine study) seropositive for a previous infection … enrolled 3249 participants, of whom 3168 (98%) continued into the 2-week quarantine period. 3076 (95%) participants …
“Among 189 seropositive participants, 19 (10%) had at least one positive PCR test for SARS-CoV-2 during the 6-week follow-up (1·1 cases per person-year). In contrast, 1079 (48%) of 2247 seronegative participants tested positive (6·2 cases per person-year). The incidence rate ratio was 0·18 (95% CI 0·11–0·28; p<0·001) …
“infected seropositive participants had viral loads that were about 10-times lower than those of infected seronegative participants (ORF1ab gene cycle threshold difference 3·95 [95% CI 1·23–6·67]; p=0·004).”
37) Associations of Vaccination and of Prior Infection With Positive PCR Test Results for SARS-CoV-2 in Airline Passengers Arriving in Qatar, Bertollini, 2021“Of 9,180 individuals with no record of vaccination but with a record of prior infection at least 90 days before the PCR test (group 3), 7694 could be matched to individuals with no record of vaccination or prior infection (group 2), among whom PCR positivity was 1.01% (95% CI, 0.80%-1.26%) and 3.81% (95% CI, 3.39%-4.26%), respectively.The relative risk for PCR positivity was 0.22 (95% CI, 0.17-0.28) for vaccinated individuals and 0.26 (95% CI, 0.21-0.34) for individuals with prior infection compared with no record of vaccination or prior infection.”
38) Natural immunity against COVID-19 significantly reduces the risk of reinfection: findings from a cohort of sero-survey participants, Mishra, 2021“Followed up with a subsample of our previous sero-survey participants to assess whether natural immunity against SARS-CoV-2 was associated with a reduced risk of re-infection (India) …
“out of the 2238 participants, 1170 were sero-positive and 1068 were sero-negative for antibody against COVID-19.
“Our survey found that only 3 individuals in the sero-positive group got infected with COVID-19 whereas 127 individuals reported contracting the infection the sero-negative group …
“from the 3 sero-positives re-infected with COVID-19, one had hospitalization, but did not require oxygen support or critical care …
“development of antibody following natural infection not only protects against re-infection by the virus to a great extent, but also safeguards against progression to severe COVID-19 disease.”
39) Lasting immunity found after recovery from COVID-19, NIH, 2021“The researchers found durable immune responses in the majority of people studied. Antibodies against the spike protein of SARS-CoV-2, which the virus uses to get inside cells, were found in 98% of participants one month after symptom onset.
“As seen in previous studies, the number of antibodies ranged widely between individuals.
“But, promisingly, their levels remained fairly stable over time, declining only modestly at 6 to 8 months after infection … virus-specific B cells increased over time.
“People had more memory B cells six months after symptom onset than at one month afterwards… levels of T cells for the virus also remained high after infection.
“Six months after symptom onset, 92% of participants had CD4+ T cells that recognized the virus… 95% of the people had at least 3 out of 5 immune-system components that could recognize SARS-CoV-2 up to 8 months after infection.”
40) SARS-CoV-2 Natural Antibody Response Persists for at Least 12 Months in a Nationwide Study From the Faroe Islands, Petersen, 2021“The seropositive rate in the convalescent individuals was above 95% at all sampling time points for both assays and remained stable over time; that is, almost all convalescent individuals developed antibodies …
“results show that SARS-CoV-2 antibodies persisted at least 12 months after symptom onset and maybe even longer, indicating that COVID-19-convalescent individuals may be protected from reinfection.”
41) SARS-CoV-2-specific T cell memory is sustained in COVID-19 convalescent patients for 10 months with successful development of stem cell-like memory T cells, Jung, 2021“ex vivo assays to evaluate SARS-CoV-2-specific CD4+ and CD8+ T cell responses in COVID-19 convalescent patients up to 317 days post-symptom onset (DPSO), and find that memory T cell responses are maintained during the study period regardless of the severity of COVID-19.
“In particular, we observe sustained polyfunctionality and proliferation capacity of SARS-CoV-2-specific T cells. Among SARS-CoV-2-specific CD4+ and CD8+ T cells detected by activation-induced markers, the proportion of stem cell-like memory T (TSCM) cells is increased, peaking at approximately 120 DPSO.”
42) Immune Memory in Mild COVID-19 Patients and Unexposed Donors Reveals Persistent T Cell Responses After SARS-CoV-2 Infection, Ansari, 2021“Analyzed 42 unexposed healthy donors and 28 mild COVID-19 subjects up to 5 months from the recovery for SARS-CoV-2 specific immunological memory.
“Using HLA class II predicted peptide megapools, we identified SARS-CoV-2 cross-reactive CD4+ T cells in around 66% of the unexposed individuals. Moreover, we found detectable immune memory in mild COVID-19 patients several months after recovery in the crucial arms of protective adaptive immunity; CD4+ T cells and B cells, with a minimal contribution from CD8+ T cells.
“Interestingly, the persistent immune memory in COVID-19 patients is predominantly targeted towards the Spike glycoprotein of the SARS-CoV-2. This study provides the evidence of both high magnitude pre-existing and persistent immune memory in Indian population.”
43) COVID-19 natural immunity, WHO, 2021“Current evidence points to most individuals developing strong protective immune responses following natural infection with SARSCoV-2.
“Within 4 weeks following infection, 90-99% of individuals infected with the SARS-CoV-2 virus develop detectable neutralizing antibodies.
“The strength and duration of the immune responses to SARS-CoV-2 are not completely understood and currently available data suggests that it varies by age and the severity of symptoms.
“Available scientific data suggests that in most people immune responses remain robust and protective against reinfection for at least 6-8 months after infection (the longest follow up with strong scientific evidence is currently approximately 8 months).”
44) Antibody Evolution after SARS-CoV-2 mRNA Vaccination, Cho, 2021“We conclude that memory antibodies selected over time by natural infection have greater potency and breadth than antibodies elicited by vaccination …
“boosting vaccinated individuals with currently available mRNA vaccines would produce a quantitative increase in plasma neutralizing activity but not the qualitative advantage against variants obtained by vaccinating convalescent individuals.”
45) Humoral Immune Response to SARS-CoV-2 in Iceland, Gudbjartsson, 2020“Measured antibodies in serum samples from 30,576 persons in Iceland … of the 1797 persons who had recovered from SARS-CoV-2 infection, 1107 of the 1215 who were tested (91.1%) were seropositive…
“results indicate risk of death from infection was 0.3% and that antiviral antibodies against SARS-CoV-2 did not decline within 4 months after diagnosis (para).”
46)  Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection, Dan, 2021“Analyzed multiple compartments of circulating immune memory to SARS-CoV-2 in 254 samples from 188 COVID-19 cases, including 43 samples at ≥ 6 months post-infection … IgG to the Spike protein was relatively stable over 6+ months.
“Spike-specific memory B cells were more abundant at 6 months than at 1 month post symptom onset.”
47) The prevalence of adaptive immunity to COVID-19 and reinfection after recovery – a comprehensive systematic review and meta-analysis of 12 011 447 individuals, Chivese, 2021“Fifty-four studies, from 18 countries, with a total of 12 011 447 individuals, followed up to 8 months after recovery, were included.
“At 6-8 months after recovery, the prevalence of detectable SARS-CoV-2 specific immunological memory remained high; IgG – 90.4% … pooled prevalence of reinfection was 0.2% (95%CI 0.0 – 0.7, I2 = 98.8, 9 studies). Individuals who recovered from COVID-19 had an 81% reduction in odds of a reinfection (OR 0.19, 95% CI 0.1 – 0.3, I2 = 90.5%, 5 studies).”
48) Reinfection Rates among Patients who Previously Tested Positive for COVID-19: a Retrospective Cohort Study, Sheehan, 2021“Retrospective cohort study of one multi-hospital health system included 150,325 patients tested for COVID-19 infection … prior infection in patients with COVID-19 was highly protective against reinfection and symptomatic disease.
“This protection increased over time, suggesting that viral shedding or ongoing immune response may persist beyond 90 days and may not represent true reinfection.”
49) Assessment of SARS-CoV-2 Reinfection 1 Year After Primary Infection in a Population in Lombardy, Italy, Vitale, 2020“The study results suggest that reinfections are rare events and patients who have recovered from COVID-19 have a lower risk of reinfection.
“Natural immunity to SARS-CoV-2 appears to confer a protective effect for at least a year, which is similar to the protection reported in recent vaccine studies.”
50) Prior SARS-CoV-2 infection is associated with protection against symptomatic reinfection, Hanrath, 2021“We observed no symptomatic reinfections in a cohort of healthcare workers … this apparent immunity to re-infection was maintained for at least 6 months …
“test positivity rates were 0% (0/128 [95% CI: 0–2.9]) in those with previous infection compared to 13.7% (290/2115 [95% CI: 12.3–15.2]) in those without (P<0.0001 χ2 test).”
51) mRNA vaccine-induced T cells respond identically to SARS-CoV-2 variants of concern but differ in longevity and homing properties depending on prior infection status, Neidleman, 2021“In infection-naïve individuals, the second dose boosted the quantity and altered the phenotypic properties of SARS-CoV-2-specific T cells, while in convalescents the second dose changed neither.
“Spike-specific T cells from convalescent vaccinees differed strikingly from those of infection-naïve vaccinees, with phenotypic features suggesting superior long-term persistence and ability to home to the respiratory tract including the nasopharynx.”
52) Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals, Grifoni, 2020“Using HLA class I and II predicted peptide ‘megapools,’ circulating SARS-CoV-2-specific CD8+ and CD4+ T cells were identified in ∼70% and 100% of COVID-19 convalescent patients, respectively. CD4+ T cell responses to spike, the main target of most vaccine efforts, were robust and correlated with the magnitude of the anti-SARS-CoV-2 IgG and IgA titers.
“The M, spike, and N proteins each accounted for 11%–27% of the total CD4+ response, with additional responses commonly targeting nsp3, nsp4, ORF3a, and ORF8, among others. For CD8+ T cells, spike and M were recognized, with at least eight SARS-CoV-2 ORFs targeted.”
53) NIH Director’s Blog: Immune T Cells May Offer Lasting Protection Against COVID-19, Collins, 2021“Much of the study on the immune response to SARS-CoV-2, the novel coronavirus that causes COVID-19, has focused on the production of antibodies.
“But, in fact, immune cells known as memory T cells also play an important role in the ability of our immune systems to protect us against many viral infections, including — it now appears — COVID-19.An intriguing new study of these memory T cells suggests they might protect some people newly infected with SARS-CoV-2 by remembering past encounters with other human coronaviruses.
“This might potentially explain why some people seem to fend off the virus and may be less susceptible to becoming severely ill with COVID-19.”
54) Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants, Wang, 2021“Our study demonstrates that convalescent subjects previously infected with ancestral variant SARS-CoV-2 produce antibodies that cross-neutralize emerging VOCs with high potency … potent against 23 variants, including variants of concern.”
55) Why COVID-19 Vaccines Should Not Be Required for All Americans, Makary, 2021“Requiring the vaccine in people who are already immune with natural immunity has no scientific support. While vaccinating those people may be beneficial — and it’s a reasonable hypothesis that vaccination may bolster the longevity of their immunity — to argue dogmatically that they must get vaccinated has zero clinical outcome data to back it.
“As a matter of fact, we have data to the contrary: A Cleveland Clinic study found that vaccinating people with natural immunity did not add to their level of protection.”
56) Protracted yet coordinated differentiation of long-lived SARS-CoV-2-specific CD8+ T cells during COVID-19 convalescence, Ma, 2021“Screened 21 well-characterized, longitudinally-sampled convalescent donors that recovered from mild COVID-19 … following a typical case of mild COVID-19, SARS-CoV-2-specific CD8+ T cells not only persist but continuously differentiate in a coordinated fashion well into convalescence, into a state characteristic of long-lived, self-renewing memory.”
57) Decrease in Measles Virus-Specific CD4 T Cell Memory in Vaccinated Subjects, Naniche, 2004“Characterized the profiles of measles vaccine (MV) vaccine-induced antigen-specific T cells over time since vaccination.
“In a cross-sectional study of healthy subjects with a history of MV vaccination, we found that MV-specific CD4 and CD8 T cells could be detected up to 34 years after vaccination.
“The levels of MV-specific CD8 T cells and MV-specific IgG remained stable, whereas the level of MV-specific CD4 T cells decreased significantly in subjects who had been vaccinated >21 years earlier.”
58) Remembrance of Things Past: Long-Term B Cell Memory After Infection and Vaccination, Palm, 2019“The success of vaccines is dependent on the generation and maintenance of immunological memory. The immune system can remember previously encountered pathogens, and memory B and T cells are critical in secondary responses to infection.
“Studies in mice have helped to understand how different memory B cell populations are generated following antigen exposure and how affinity for the antigen is determinant to B cell fate …
“upon re-exposure to an antigen the memory recall response will be faster, stronger, and more specific than a naïve response.
“Protective memory depends first on circulating antibodies secreted by LLPCs. When these are not sufficient for immediate pathogen neutralization and elimination, memory B cells are recalled.”
59) SARS-CoV-2 specific memory B-cells from individuals with diverse disease severities recognize SARS-CoV-2 variants of concern, Lyski, 2021“Examined the magnitude, breadth and durability of SARS-CoV-2 specific antibodies in two distinct B-cell compartments: long-lived plasma cell-derived antibodies in the plasma, and peripheral memory B-cells along with their associated antibody profiles elicited after in vitro stimulation.
“We found that magnitude varied amongst individuals, but was the highest in hospitalized subjects. Variants of concern (VoC) -RBD-reactive antibodies were found in the plasma of 72% of samples in this investigation, and VoC-RBD-reactive memory B-cells were found in all but 1 subject at a single time-point.
“This finding, that VoC-RBD-reactive MBCs are present in the peripheral blood of all subjects including those that experienced asymptomatic or mild disease, provides a reason for optimism regarding the capacity of vaccination, prior infection, and/or both, to limit disease severity and transmission of variants of concern as they continue to arise and circulate.”
60) Exposure to SARS-CoV-2 generates T-cell memory in the absence of a detectable viral infection, Wang, 2021“T-cell immunity is important for recovery from COVID-19 and provides heightened immunity for re-infection. However, little is known about the SARS-CoV-2-specific T-cell immunity in virus-exposed individuals …
“report virus-specific CD4+ and CD8+ T-cell memory in recovered COVID-19 patients and close contacts … close contacts are able to gain T-cell immunity against SARS-CoV-2 despite lacking a detectable infection.”
61) CD8+ T-Cell Responses in COVID-19 Convalescent Individuals Target Conserved Epitopes From Multiple Prominent SARS-CoV-2 Circulating Variants, Redd, 2021and Lee, 2021“The CD4 and CD8 responses generated after natural infection are equally robust, showing activity against multiple ‘epitopes’ (little segments) of the spike protein of the virus.
“For instance, CD8 cells responds to 52 epitopes and CD4 cells respond to 57 epitopes across the spike protein, so that a few mutations in the variants cannot knock out such a robust and in-breadth T cell response …
“only 1 mutation found in Beta variant-spike overlapped with a previously identified epitope (1/52), suggesting that virtually all anti-SARS-CoV-2 CD8+ T-cell responses should recognize these newly described variants.”
62) Exposure to common cold coronaviruses can teach the immune system to recognize SARS-CoV-2,La Jolla, Crotty and Sette, 2020“Exposure to common cold coronaviruses can teach the immune system to recognize SARS-CoV-2”
63) Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans, Mateus, 2020“Found that the pre-existing reactivity against SARS-CoV-2 comes from memory T cells and that cross-reactive T cells can specifically recognize a SARS-CoV-2 epitope as well as the homologous epitope from a common cold coronavirus.
“These findings underline the importance of determining the impacts of pre-existing immune memory in COVID-19 disease severity.”
64) Longitudinal observation of antibody responses for 14 months after SARS-CoV-2 infectionDehgani-Mobaraki, 2021“Better understanding of antibody responses against SARS-CoV-2 after natural infection might provide valuable insights into the future implementation of vaccination policies.
“Longitudinal analysis of IgG antibody titers was carried out in 32 recovered COVID-19 patients based in the Umbria region of Italy for 14 months after Mild and Moderately-Severe infection …
“study findings are consistent with recent studies reporting antibody persistency suggesting that induced SARS-CoV-2 immunity through natural infection, might be very efficacious against re-infection (>90%) and could persist for more than six months.
“Our study followed up patients up to 14 months demonstrating the presence of anti-S-RBD IgG in 96.8% of recovered COVID-19 subjects.”
65) Humoral and circulating follicular helper T cell responses in recovered patients with COVID-19, Juno, 2020“Characterized humoral and circulating follicular helper T cell (cTFH) immunity against spike in recovered patients with coronavirus disease 2019 (COVID-19).
“We found that S-specific antibodies, memory B cells and cTFH are consistently elicited after SARS-CoV-2 infection, demarking robust humoral immunity and positively associated with plasma neutralizing activity.”
66) Convergent antibody responses to SARS-CoV-2 in convalescent individuals, Robbiani, 2020“149 COVID-19-convalescent individuals…antibody sequencing revealed the expansion of clones of RBD-specific memory B cells that expressed closely related antibodies in different individuals.
“Despite low plasma titres, antibodies to three distinct epitopes on the RBD neutralized the virus with half-maximal inhibitory concentrations (IC50 values) as low as 2 ng ml−1.”
67) Rapid generation of durable B cell memory to SARS-CoV-2 spike and nucleocapsid proteins in COVID-19 and convalescence, Hartley, 2020“COVID-19 patients rapidly generate B cell memory to both the spike and nucleocapsid antigens following SARS-CoV-2 infection … RBD- and NCP-specific IgG and Bmem cells were detected in all 25 patients with a history of COVID-19.”
68) Had COVID? You’ll probably make antibodies for a lifetime, Callaway, 2021“People who recover from mild COVID-19 have bone-marrow cells that can churn out antibodies for decades … the study provides evidence that immunity triggered by SARS-CoV-2 infection will be extraordinarily long-lasting.”
69) A majority of uninfected adults show preexisting antibody reactivity against SARS-CoV-2, Majdoubi, 2021In greater Vancouver Canada, “using a highly sensitive multiplex assay and positive/negative thresholds established in infants in whom maternal antibodies have waned, we determined that more than 90% of uninfected adults showed antibody reactivity against the spike protein, receptor-binding domain (RBD), N-terminal domain (NTD), or the nucleocapsid (N) protein from SARS-CoV-2.”
70) SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19, Braun, 2020“The results indicate that spike-protein cross-reactive T cells are present, which were probably generated during previous encounters with endemic coronaviruses.”
71) Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection, Wang, 2021“A cohort of 63 individuals who have recovered from COVID-19 assessed at 1.3, 6.2 and 12 months after SARS-CoV-2 infection … the data suggest that immunity in convalescent individuals will be very long lasting.”
72) One Year after Mild COVID-19: The Majority of Patients Maintain Specific Immunity, But One in Four Still Suffer from Long-Term Symptoms, Rank, 2021“Long-lasting immunological memory against SARS-CoV-2 after mild COVID-19.”
73) IDSA, 2021“Immune responses to SARS-CoV-2 following natural infection can persist for at least 11 months …
“natural infection (as determined by a prior positive antibody or PCR-test result) can confer protection against SARS-CoV-2 infection.”
74) Assessment of protection against reinfection with SARS-CoV-2 among 4 million PCR-tested individuals in Denmark in 2020: a population-level observational study, Holm Hansen, 2021Denmark, “during the first surge (ie, before June, 2020), 533 381 people were tested, of whom 11 727 (2·20%) were PCR positive, and 525 339 were eligible for follow-up in the second surge, of whom 11 068 (2·11%) had tested positive during the first surge.“Among eligible PCR-positive individuals from the first surge of the epidemic, 72 (0·65% [95% CI 0·51–0·82]) tested positive again during the second surge compared with 16 819 (3·27% [3·22–3·32]) of 514 271 who tested negative during the first surge (adjusted RR 0·195 [95% CI 0·155–0·246]).”
75) Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity, Moderbacher, 2020“Adaptive immune responses limit COVID-19 disease severity…multiple coordinated arms of adaptive immunity control better than partial responses …
“completed a combined examination of all three branches of adaptive immunity at the level of SARS-CoV-2-specific CD4+ and CD8+ T cell and neutralizing antibody responses in acute and convalescent subjects. SARS-CoV-2-specific CD4+ and CD8+ T cells were each associated with milder disease.
“Coordinated SARS-CoV-2-specific adaptive immune responses were associated with milder disease, suggesting roles for both CD4+ and CD8+ T cells in protective immunity in COVID-19.”
76) Detection of SARS-CoV-2-Specific Humoral and Cellular Immunity in COVID-19 Convalescent Individuals, Ni, 2020“Collected blood from COVID-19 patients who have recently become virus-free, and therefore were discharged, and detected SARS-CoV-2-specific humoral and cellular immunity in eight newly discharged patients.
“Follow-up analysis on another cohort of six patients 2 weeks post discharge also revealed high titers of immunoglobulin G (IgG) antibodies.
“In all 14 patients tested, 13 displayed serum-neutralizing activities in a pseudotype entry assay. Notably, there was a strong correlation between neutralization antibody titers and the numbers of virus-specific T cells.”
77) Robust SARS-CoV-2-specific T-cell immunity is maintained at 6 months following primary infection, Zuo, 2020“Analysed the magnitude and phenotype of the SARS-CoV-2 cellular immune response in 100 donors at six months following primary infection and related this to the profile of antibody level against spike, nucleoprotein and RBD over the previous six months.
“T-cell immune responses to SARS-CoV-2 were present by ELISPOT and/or ICS analysis in all donors and are characterised by predominant CD4+ T cell responses with strong IL-2 cytokine expression …
“functional SARS-CoV-2-specific T-cell responses are retained at six months following infection.”
78) Negligible impact of SARS-CoV-2 variants on CD4+ and CD8+ T cell reactivity in COVID-19 exposed donors and vaccinees, Tarke, 2021“Performed a comprehensive analysis of SARS-CoV-2-specific CD4+ and CD8+ T cell responses from COVID-19 convalescent subjects recognizing the ancestral strain, compared to variant lineages B.1.1.7, B.1.351, P.1, and CAL.20C as well as recipients of the Moderna (mRNA-1273) or Pfizer/BioNTech (BNT162b2) COVID-19 vaccines …
“the sequences of the vast majority of SARS-CoV-2 T cell epitopes are not affected by the mutations found in the variants analyzed.
“Overall, the results demonstrate that CD4+ and CD8+ T cell responses in convalescent COVID-19 subjects or COVID-19 mRNA vaccinees are not substantially affected by mutations.”
79) A 1 to 1000 SARS-CoV-2 reinfection proportion in members of a large healthcare provider in Israel: a preliminary report, Perez, 2021Israel, “out of 149,735 individuals with a documented positive PCR test between March 2020 and January 2021, 154 had two positive PCR tests at least 100 days apart, reflecting a reinfection proportion of 1 per 1000.”
80) Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patients, Iyer, 2020“Measured plasma and/or serum antibody responses to the receptor-binding domain (RBD) of the spike (S) protein of SARS-CoV-2 in 343 North American patients infected with SARS-CoV-2 (of which 93% required hospitalization) up to 122 days after symptom onset and compared them to responses in 1548 individuals whose blood samples were obtained prior to the pandemic …
“IgG antibodies persisted at detectable levels in patients beyond 90 days after symptom onset, and seroreversion was only observed in a small percentage of individuals.
“The concentration of these anti-RBD IgG antibodies was also highly correlated with pseudovirus NAb titers, which also demonstrated minimal decay. The observation that IgG and neutralizing antibody responses persist is encouraging, and suggests the development of robust systemic immune memory in individuals with severe infection.”
81) A population-based analysis of the longevity of SARS-CoV-2 antibody seropositivity in the United States, Alfego, 2021“To track population-based SARS-CoV-2 antibody seropositivity duration across the United States using observational data from a national clinical laboratory registry of patients tested by nucleic acid amplification (NAAT) and serologic assays …
“specimens from 39,086 individuals with confirmed positive COVID-19 … both S and N SARS-CoV-2 antibody results offer an encouraging view of how long humans may have protective antibodies against COVID-19, with curve smoothing showing population seropositivity reaching 90% within three weeks, regardless of whether the assay detects N or S-antibodies.
“Most importantly, this level of seropositivity was sustained with little decay through ten months after initial positive PCR.”

Originally published by Brownstone Institute.

Survey Reveals Evangelicals More Likely To Live Out Their Faith

Evangelical-affiliated churches had more “practicing” Christians than other mainstream denominations, says a recent American Bible Society (ABS) study.

On Thursday, the ABS released the findings of a survey titled “The Bible in the American Church.” The survey was part of ABS’ 11th annual State of the Bible report.

The Christian Post reports that the chapter differentiates between practicing Christians and professing believers. It described practicing believers as those who go to religious activities “at least once a month,” and who firmly believe that their religion is extremely important to them. ABS adds that practicing Christians have also “incorporated the faith into their life and routine in a transformative way.”

Self-described Christians, on the other hand, are people “who simply say they believe.”

The survey conducted also found that among individuals who call themselves evangelicals, 42% consider themselves to be actively involved in their faith. Other denominations have much lower percentages of active Christians: 31% of predominantly Black Protestants, 28% of mainstream Protestants, and 22% of Catholics.

Christians were also asked about their relationship with the Bible as part of the study.

Only 67% of respondents are “Scripture engaged,” according to the study, while 29% are in the “movable middle” and 4% are “Scripture disengaged.”

Scripture-engaged Christians, according to the ABS, are those who “interact with the Bible regularly” and have a Scripture engagement score of at least 100.

The “movable middle” includes participants who scored between 70 and 99 on the Scripture engagement scale. Those in the moveable center are those who “sporadically interact with the Bible,” while those in the extremes “periodically open the Bible as a source of spiritual insight and wisdom.”

Christians who “interact infrequently with the Bible” are classified as “Bible disengaged.” The Bible also seems to have little impact on the Bible disengaged everyday life.

The other findings state that 75% of practicing Christians read the Bible weekly while 84% do so monthly. Conversely, just 28% of non-practicing Christians read the Bible weekly, and 39% do so monthly.

Evangelicals (93%) and historically black Protestants (87%) had the greatest weekly Bible reading rates (80 percent).

The poll, which included 3,354 people, was conducted in January.

In a related survey by the Pew Research Center, nearly half of evangelical Christians (49%) currently attend religious services in person without any kind of COVID-related limitations.

Faithwire notes that as per the survey, an astounding 64% of those who claim to “typically attend services at least once or twice a month,” actually went to church that month.

Pew’s research found that evangelical Protestants, White (non-Hispanic) Americans, and Republicans are more likely than other religious groups to believe that their churches should remain open during a pandemic.

Compared to July of last year and early this year, just 6% of respondents reported their houses of worship were still completely closed.

“The resumption of in-person attendance,” observed Pew Forum, “has been accompanied by a decline in the share of both U.S. adults overall and regular worshippers who say they have watched religious services online or on TV in the past month.”

Secret Vaccine Contracts Reveal How Pfizer Strong-Armed Governments to Maximize Profits

In a report published Tuesday, Public Citizen exposed how Pfizer, through secret contracts, used its monopoly on COVID vaccines to extract concessions from “desperate” governments.

Pfizer has used its position as a producer of one of the leading COVID-19 vaccines to “silence governments, throttle supply, shift risk, and maximize profits” through secret contracts with countries around the world, according to a Public Citizen report published Tuesday.

“Behind closed doors, Pfizer wields its power to extract a series of concerning concessions from governments,” report author Zain Rizvi, law and policy researcher at Public Citizen’s Access to Medicines program, said in a statement. “The global community cannot allow pharmaceutical corporations to keep calling the shots.”

The new report begins by noting February reporting about accusations of Pfizer — an American pharmaceutical giant that developed its mRNA vaccine with the German firm BioNTech — “bullying” Latin American governments during contract negotiations for doses.

Public Citizen obtained unredacted term sheets, drafts or final agreements between Pfizer and Albania, Brazil, Colombia, the Dominican Republic, the European Commission and Peru. The consumer rights advocacy group also examined redacted contracts with Chile, the U.S., and the U.K.

Based on those contracts, the report identifies six tactics Pfizer is using to serve the company rather than public health in the midst of a deadly pandemic:

1. Pfizer reserves the right to silence governments

The Brazilian government complained earlier this year that the company insisted on “unfair and abusive” terms but ultimately accepted a contract that “waived sovereign immunity; imposed no penalties on Pfizer for late deliveries; agreed to resolve disputes under a secret private arbitration under the laws of New York; and broadly indemnified Pfizer for civil claims.”

Brazil also agreed to a nondisclosure provision similar to those found in contracts with the European Commission and the U.S. government.

2. Pfizer controls donations

Again using Brazil as an example, the report points out that the South American nation must first get a go-ahead from Pfizer to accept donations or buy its vaccines from others. The country is also barred from “donating, distributing, exporting, or otherwise transporting the vaccine outside Brazil without Pfizer’s permission.”

3. Pfizer secured an “IP waiver” for itself

Pfizer CEO Albert Bourla “has emerged as a strident defender of intellectual property in the pandemic,” the report says, noting his opposition to a proposal that members of the World Trade Organization who signed on to the Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS) waive IP protections for COVID-19 vaccines and treatments during the crisis.

“But, in several contracts, Pfizer seems to recognize the risk posed by intellectual property to vaccine development, manufacturing, and sale,” Public Citizen explains. “The contracts shift responsibility for any intellectual property infringement that Pfizer might commit to the government purchasers. As a result, under the contract, Pfizer can use anyone’s intellectual property it pleases — largely without consequence.”

4. Private arbitrators, not public courts, decide disputes in secret

While the U.K. contract requires that disputes are settled by secret panel of three private arbitrators under the Rules of Arbitration of the International Chamber of Commerce, the report says, “the Albania draft contract and Brazil, Chile, Colombia, Dominican Republic, and Peru agreements require the governments to go further, with contractual disputes subject to ICC arbitration applying New York law.”

5. Pfizer can go after state assets

“Pfizer required Brazil, Chile, Colombia, the Dominican Republic, and Peru to waive sovereign immunity,” the report highlights, detailing that the doctrine can sometimes protect states from companies trying to enforce decisions reached by the previously noted secret arbitral panels. Some of the contracts enable the company to “request that courts use state assets as a guarantee that Pfizer will be paid an arbitral award and/or use the assets to compensate Pfizer if the government does not pay,” according to Public Citizen.

6. Pfizer calls the shots on key decisions

“What happens if there are vaccine supply shortages? In the Albania draft contract and the Brazil and Colombia agreement, Pfizer will decide adjustments to the delivery schedule based on principles the corporation will decide” the report notes, concluding that “under the vast majority of contracts, Pfizer’s interests come first.”

Public Citizen calls on world leaders, especially U.S. President Joe Biden, to “push back” against Pfizer’s negotiating tactics and “rein in” its monopoly power.

According to the group, the Biden administration can “call on Pfizer to renegotiate existing commitments and pursue a fairer approach in the future” as well as “further rectify the power imbalance by sharing the vaccine recipe, under the Defense Production Act, to allow multiple producers to expand vaccine supplies.”

The U.S. administration “can also work to rapidly secure a broad waiver of intellectual property rules,” the report adds, declaring that “a wartime response against the virus demands nothing less.”

In response to Public Citizen’s report, Sharon Castillo, a spokesperson for Pfizer, told The Washington Post that confidentiality clauses were “standard in commercial contracts” and “intended to help build trust between the parties, as well as protect the confidential commercial information exchanged during negotiations and included in final contracts.”

Castillo also said that “Pfizer has not interfered and has absolutely no intention of interfering with any country’s diplomatic, military, or culturally significant assets,” adding that “to suggest anything to the contrary is irresponsible and misleading.”

Meanwhile, Peter Maybarduk, director of Public Citizen’s Access to Medicines program, accused Pfizer of “taking advantage of countries’ desperation” with the far-reaching contracts.

“Most of us have sacrificed during the pandemic; staying distant to protect family and friends,” Maybarduk said Tuesday. “Pfizer went the other way, using its control of scarce vaccines to win special privileges, from people that have little choice.”