A recent study published in the medical journal Cureus found that 27.11% of those who received COVID-19 mRNA vaccines in Saudi Arabia had “cardiac complications.”
“Due to the scarcity of data on vaccine safety specific to the Saudi population, a dedicated study becomes imperative to uncover the incidence, nature, and associated factors of self-reported physician-diagnosed cardiac complications post mRNA vaccination,” the researchers wrote.
While the study’s authors claimed cardiac complications were “infrequent,” they noted the implications of heart issues are “significant.”
“Grasping and comprehending these complications after mRNA vaccination is vital for a comprehensive assessment of vaccine safety and for guiding public health measures,” the study read. “Continuous monitoring of vaccine safety is paramount, and investigating self-reported physician-diagnosed cardiac complications post mRNA vaccination provides real-world data to complement clinical trial findings, enhancing our understanding of the long-term safety profile of these vaccines.”
The study provided 804 participants with a questionnaire analyzing possible heart problems following an mRNA inoculation.
Fourteen percent of those with heart problems experienced complications within one month of vaccination.
Another 15% of those vaccinated spent time in a critical care unit.
Nearly 10% (9.45%) of participants received treatment for heart problems for more than 12 months after inoculation. At the time of the study, 7.11% were under continuous treatment for complications.
Research from Germany found that spike proteins from mRNA COVID-19 vaccines form in human heart cells 48 hours after vaccination.
The research, published in the British Journal of Pharmacology, revealed that spike proteins were seen after the administration of both the Pfizer and Moderna vaccines.
Different abnormalities were detected between the two mRNA vaccines, however. Heart contractions following the Pfizer COVID-19 vaccine were stronger and sustained, likely due to the increased levels of protein kinase A (PKA).
PKA levels affect heart performance.
Cells with the Moderna mRNA vaccine contributed to irregular heart contractions and affected the RyR2 receptors, which coordinate heart contractions with calcium.
“Both RyR2 impairment and sustained PKA activation may significantly increase the risk of acute cardiac events,” the authors wrote.
